Advances in Clinical Chemistry, Vol. 12 - download pdf or read online

By Oscar Bodansky (ed.), C.P. Stewart (ed.)

ISBN-10: 0120103125

ISBN-13: 9780120103126

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The principal metabolic response to cold exposure is increased heat production, with increased food and oxygen consumption, although nest-building is not unimportant. On theoretical grounds, one might expect cold exposure to result in increased tissue weight in liver, kidney, and gut, secondary to increased food consumption. Adrenal hyperplasia would not be surprising, and increased insulation of the pelt would be expected. This is apparently achieved mainly by increased fur growth, and the lighter-weight skin reported by Barnett on cold exposure may be due t o energy demands preventing peripheral fat deposition.

There may thus be a decreased synthesis of methycobalamin or a n increased catabolism or leakage from the liver-or combination of these causes. The method used did not determine the nonextractable cobalamin, so that a disappearance into a nonextractable form could have been the cause (L9). 6. 1. EFFECTS OF DIMINISHED FOOD INTAKE ON THE METABOLIC RESPONSE As described above, it is now fairly certain that the source of most of the additional nitrogen lost in the urine in the “flow” phase of the metabolic response to injury is labile body protein, and not liver or gut 24 D.

K l ) have provided information concerning the pattern of changes in blood volume and proteins which follow partial starvation and the recovery process. Although Cairnie et al. ( C l ) found no increase in heat production or in nitrogen excretion following fracture in the protein-depleted rat indicative t ha t f a t was not being mobilized in the absence of labile protein, nevertheless some involvement of lipid metabolism seems t o occur. Birke et al. (B8) have reported high levels of circulating free fatty acids and reduced levels of cholesterol, with no change in triglyceride level in severely burned patients.

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Advances in Clinical Chemistry, Vol. 12 by Oscar Bodansky (ed.), C.P. Stewart (ed.)


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