By Frank J. Dixon
"The sequence which all immunologists need." --The Pharmaceutical magazine "Advances in Immunology needs to locate itself one of the such a lot energetic volumes within the libraries of our universities and institutions." --Science "Deserves an enduring position in biomedical libraries as an reduction in examine and in educating" --Journal of Immunological tools "A provocative and scholarly evaluate of analysis" --Journal of the yank scientific organization "Provides a very worthwhile resource of reference and plenty of stimulating ideas...the major repository of data in a swiftly devloping topic" --The Lancet "Provides unrivalled price in either educational and monetary phrases and may be bought by way of demanding pressed librarians as a tremendous precedence to be jealously defended." --Journal of scientific Microbiology "A very worthy serial publication...no severe pupil of immunology can manage to pay for to be with out it." --Archives of Biochemistry and Biophysics Key positive aspects * concentrate on parts of the V(D)J recombination equipment that may be on the topic of illnesses in people and animals * regulate of the supplement method by means of regulate of C3/C5 convertase on host cells, regulate of fluid section C3/C5 convertases, regulate of fluid section MAC, and keep an eye on of deposited MAC * Immunodeficiency as a result of an entire absence of MHC category II expression and trans-acting elements controlling transcription * present wisdom of IL-2R signaling, highlighting IL-2 signaling, and T-cell progress rules * practical function of CD40 in cells, the in vivo value of CD40-CD40-L interactions, and the sign transduction equipment activated following crosslinking of the CD40 antigen * Integrative method of higher comprehend the saw heterogeneity of anyone reaction to allergens * law of isotype specificity, swap recombination legislation, and the mechanism of switching * lymphocyte-specific proteins, RAG1 and RAG2, begin V(D)J recombination of antigen receptor genes
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Additional info for Advances in Immunology, Vol. 61
Manuscript in preparation). 10. , 1995). 11. , submitted for publication). )Iincreases fibroblast CD40 expression. CD40 ligation also results in increased production of GM-CSF and MIP-la by synoviocytes. Thus, as summarized in Fig. 9, CD40 appears to be functional on multiple cell types. VI. In Vivo Role of CD40-CD40-1 Interactions A. , I N THE 42 CEES VAN KOOTEN A N D JACQUES RANCHEHEAU Fic: 9. Functional consequences of CD40 triggering on different cell types. Activation includes increase in cell size and alteration of phenotype.
At this stage, interactions between T cells and FDCs are likely to occur. In particular, FDCs may be induced to proliferate as indicated by the considerably denser FDC network in secondary follicles by contrast to primary follicles and by the existence of Ki67+ FDCs in secondary follicles. , submitted for publication). , 1995) (Fig. 12). In fact, such as mechanism prevents the possibility that immune responses may be dominated by only a few B cell clones that would prevent the building of a repertoire vast enough to match the extreme diversity of potentially harmful antigens.
These cells may express Fas-L and thus may represent an ultimate selection gate to kill nonselected B cells in a Fas/Fas-L-dependent interaction. (iii) Centrocytes display antigen receptors that acquired an affinity for autoantigens (“B auto” in Fig. 11B). A very large repertoire of autoantigens is likely to be present within the germinal center microenvironment. The 52 CEES VAN KOOTEN A N D JACQUES RANCHEREAU A B cell T cell IT - ceii activation A CD4OL 1 I TCR/CD3 MHC-I1 CD4 Ag CD40-L CD40 B cell activation Fas-L Fas Terminate responses FIG 12.
Advances in Immunology, Vol. 61 by Frank J. Dixon